Eli Lilly’s retatrutide just posted 28.3% mean total body weight loss in TRIUMPH-1 phase 3. That’s ~70 lbs off a 248 lb baseline in 80 weeks. For context, tirzepatide peaked at ~22.5%. This is not a small gap.
Why so much higher? Retatrutide is a triple agonist - GIP, GLP-1, and glucagon. That glucagon receptor activation raises resting energy expenditur…
