Thoughts on Healthcare Markets and Technology

Thoughts on Healthcare Markets and Technology

Understanding Liquidation Preferences and Exit Waterfalls in Healthcare Angel Deals

Trey Rawles's avatar
Trey Rawles
Nov 01, 2025
∙ Paid
1
Share

Disclaimer: The thoughts and opinions expressed in this essay are my own and do not reflect those of my employer.

Table of Contents

Abstract

The Dinner Party That Cost Fifty Million Dollars

The Fundamental Architecture of Liquidation Preferences

When Preferences Become Weapons

The Healthcare Multiplier Effect

Reading the Tea Leaves in Term Sheets

The Math That Matters

Conclusion

Abstract

Liquidation preferences represent one of the most consequential yet frequently misunderstood components of venture financing in healthcare technology. This essay examines the mechanics of liquidation preferences and exit waterfalls through the lens of healthcare angel investments, exploring how these contractual provisions fundamentally alter the distribution of proceeds in acquisition and liquidation scenarios. Key topics include:

- The structural mechanics of participating versus non-participating preferences

- The multiplicative impact of preference stacks in multi-round financing scenarios

- Healthcare-specific considerations including regulatory exit constraints and strategic acquirer dynamics

- Quantitative modeling of waterfall scenarios across various exit multiples

- Practical guidance for angels navigating term sheet negotiations in the healthcare sector

The essay emphasizes that in healthcare deals, where exit multiples often cluster between two and four times invested capital due to regulatory complexity and buyer concentration, liquidation preference terms can swing outcomes by twenty to forty percent of total proceeds, making these provisions as important as valuation itself.

The Dinner Party That Cost Fifty Million Dollars

Keep reading with a 7-day free trial

Subscribe to Thoughts on Healthcare Markets and Technology to keep reading this post and get 7 days of free access to the full post archives.

Already a paid subscriber? Sign in
© 2025 Trey Rawles
Privacy ∙ Terms ∙ Collection notice
Start your SubstackGet the app
Substack is the home for great culture